Problematic or Non-Compliant Patient Examples Need for variation in dosage form (e.g. liquid vs. solid dosage form). A different strength is needed other than what is commercially available. Allergic to dyes or fillers in capsules. Natural hormones are needed rather than synthetic hormones. The medicine of choice has been discontinued. Problematic toenail conditions. Impotence or infertility: no improvement. Drug regimen not being taken due to taste. The problem is not responding to conventional treatment. Inflammation in the joint not getting better and causing gastric side effects. Nausea still not under control. Difficulty swallowing.

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